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staurosporine
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
CYP1A1
CXCL1
TP53I3
CXCL8
CYR61
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Pathway Enrichment
Most Correlated Biogroups
heterocyclic compound binding
organic cyclic compound binding
regulation of nitrogen compound metabolic process
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
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Curated Studies
Most Correlated Studies
Acute myeloid leukemia MV-4-11 cells with drug sensitivity or resistance to PKC412
Embryonic gene expression in response to the antineoplastic agent PKC412
Neural 3D tissue constructs from H1 ESC-derived precursor cells treated with neurotoxic chemicals
Triple negative breast cancer cell lines treated with PKC412
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
Curcumin protects against staurosporine toxicity in rat neurons.
Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi.
Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurospo…
Staurosporine and its evolving role in inhibition of growth in malignant tumors.
Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite…
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Clinical Trials
Most Relevant Clinical Trials
A Phase I Trial of Continuous Infusion UCN-01 in Patients With Refractory Neoplasms
Flavopiridol in Treating Patients With Unresectable or Metastatic Kidney Cancer
Impact of Maternal Pomegranate Juice on Brain Injury in Infants With Intrauterine Growth Restriction…
Midostaurin in Treating Older Patients With Mutated Acute Myeloid Leukemia Post-Transplant
Phase I Combination of Midostaurin, Bortezomib, and Chemo in Relapsed/Refractory Acute Myeloid Leuke…
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