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tak 242
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
TXNIP
CRIP1
ADGRE1
ANO1
KCNJ15
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Pathway Enrichment
Most Correlated Biogroups
cytosol
vesicle
organic cyclic compound binding
heterocyclic compound binding
regulation of nitrogen compound metabolic process
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
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Literature
Most Relevant Literature
TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflamm…
TAK-242 Ameliorates Hepatic Fibrosis by Regulating the Liver-Gut Axis.
Inhibition of Toll-like receptor 4 pathway by TAK242 protects the liver in sepsis].
Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflamm…
Pharmacological inhibition of TLR4-NF-κB signaling by TAK-242 attenuates hydrocephalus after intrave…
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Clinical Trials
Most Relevant Clinical Trials
A Study of MCV-101 (Also Known as TAK-186) in Adults With Advanced or Metastatic Cancer
Phase I Open-label Study to Evaluate Pharmacokinetics of TAK-272 in Participants With Renal or Hepat…
A Phase 2 Dose-finding Study of TAK-272 in Participants With Type 2 Diabetes Mellitus and Microalbum…
Comparison of TAK-438 (Vonoprazan) to Lansoprazole in the Treatment of Duodenal Ulcer Participants W…
Study of TAK-875 in Adults With Type 2 Diabetes and Cardiovascular Disease or Risk Factors for Cardi…
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