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thapsigargin
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Summary
General Info
Genetic Markers
Most Correlated Genes
DDIT3
HERPUD1
TRIB3
HSPA5
CRELD2
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Pathway Enrichment
Most Correlated Biogroups
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
FISCHER_DREAM_TARGETS
DODD_NASOPHARYNGEAL_CARCINOMA_DN
LEE_BMP2_TARGETS_DN
nucleoplasm
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Curated Studies
Most Correlated Studies
Cancer cell lines exposed to disulfide bond inhibitors or anoxic conditions
Mouse embryonic fibroblasts treated with thapsigargin; free and polysome associated RNA
Fibroblasts from SIAH1/SIAH2 knockouts with low glucose/oxygen, tunicamycin, or thapsigargin
Cardiomyocytes (mature and progenitors) treated with thapsigargin, tunicamycin or halofuginone
Neuroblastoma cell line SH-SY5Y treated with thapsigargin, tunicamycin, or atrazine
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Literature
Most Relevant Literature
Thapsigargin: key to new host-directed coronavirus antivirals?
Thapsigargin blocks electromagnetic field-elicited intracellular Ca2+ increase in HEK 293 cells.
Rh(I)-Catalyzed Allenic Pauson-Khand Reaction to Access the Thapsigargin Core: Influence of Furan an…
Thapsigargin-From Traditional Medicine to Anticancer Drug.
Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.
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Clinical Trials
Most Relevant Clinical Trials
Dose-Escalation Phase 1 Study of G-202 (Mipsagargin) in Patients With Advanced Solid Tumors
Efficacy, Safety and CNS Exposure of G-202 (Mipsagargin) in Patients With Recurrent or Progressive G…
Efficacy and Safety of G-202 in PSMA-Positive Glioblastoma
Study of G-202 (Mipsagargin) as Second-Line Therapy Following Sorafenib in Hepatocellular Carcinoma
Safety and Activity of G-202 in Patients With Clear Cell Renal Cell Carcinoma That Expresses PSMA
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