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topoisomerase ii inhibitor
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
XIST
NPR3
ATF3
FOSB
RGCC
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Pathway Enrichment
Most Correlated Biogroups
cell periphery
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
cell differentiation
DODD_NASOPHARYNGEAL_CARCINOMA_DN
BLALOCK_ALZHEIMERS_DISEASE_DN
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Curated Studies
Most Correlated Studies
Granule neuron progenitor cells from cerebellum of CHD7 mutant or wildtype mice treated with ICRF193
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
Retinal pigment epithelium hTERT RPE-1 cells treated with merbarone
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dep…
Integrating molecular docking, DFT and CoMFA/CoMSIA approaches for a series of naphthoquinone fused …
The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia …
A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis …
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): ant…
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Clinical Trials
Most Relevant Clinical Trials
Phase I/II Trial of S65487 Plus Azacitidine in Acute Myeloid Leukemia
A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmon…
Phase I/II Trial of Valproic Acid and Karenitecin for Melanoma
Phase II Study to Evaluate the Efficacy and Safety of TLC388 for Differentiated Neuroendocrine Carci…
Phase II Avastin + Bortezomib for Patients With Recurrent Malignant Glioma
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