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QuickView for ucn 01 (compound)


Genetic Markers

Most Correlated Genes

  1. TP53I3
  2. AHRR
  3. CXCL1
  4. CYR61
  5. ALDH1A3
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Pathway Enrichment

Most Correlated Biogroups

  1. FISCHER_DREAM_TARGETS
  2. GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
  3. KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
  4. FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS
  5. PUJANA_CHEK2_PCC_NETWORK
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Curated Studies

Most Correlated Studies

  1. HCT116 colon carcinoma cells - gene expression profiles in response to Chk1 inhibition or cisplatin
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Literature

Most Relevant Literature

  1. The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compo…
  2. Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells agai…
  3. Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.
  4. MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by …
  5. UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA dam…
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Clinical Trials

Most Relevant Clinical Trials

  1. A Phase II Study of UCN-01 in Metastatic Melanoma
  2. Cytarabine and UCN-01 in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia or…
  3. A Phase I Trial of Continuous Infusion UCN-01 in Patients With Refractory Neoplasms
  4. Fluorouracil Plus UCN-01 in Treating Patients With Advanced or Refractory Solid Tumors
  5. UCN-01 and Carboplatin in Treating Patients With Advanced Solid Tumors
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