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actin filament severing
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Spleen
Myeloid cells of peripheral blood
T Lymphocyte (CD4+) of peripheral blood
Coronary artery
Monocyte of peripheral blood
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Disease Atlas
Most Correlated Diseases
Bacterial sepsis of newborn
Sepsis due to coagulase negative Staphylococcus
Multiple-resistant Staphylococcus aureus infection
Duchenne muscular dystrophy
Vesicular stomatitis Indiana virus disease
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Pharmaco Atlas
Most Correlated Compounds
flavopiridol
IST5-002
CGP 60474
BMS 387032
rimcazole
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Knockdown Atlas
Most Correlated Gene Perturbations
NOLC1
CAMK1
PTPN6
CDO1
UBR5
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
L1000 CMAP - Breast cancer MCF7.101 cells with CRISPR targeted gene knockouts
L1000 CMAP - Skeletal muscle SKL.C cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
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Literature
Most Relevant Literature
Competitive displacement of cofilin can promote actin filament severing.
Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament seve…
Biophysics of actin filament severing by cofilin.
Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in ac…
Cofilin-linked changes in actin filament flexibility promote severing.
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Clinical Trials
Most Relevant Clinical Trials
Effect of 15% Eflornithine Hydrochloride Cream on African-American Males With Pseudofolliculitis Bar…
Investigation of Effects of Physiotherapy Interventions on Mechanical Properties of Muscle in Head a…
Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activit…
The Association Between LPCAT1 Genetic Polymorphism and Stress Biomarkers in Neonatal Respiratory Di…
Efficacy and Safety Study Comparing CPL409116 to Placebo in Participants With Active Rheumatoid Arth…
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