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QuickView for Mre11 complex (biogroup)


Body Atlas

Most Correlated Tissues

  1. Ovary
  2. Pancreas
  3. Kidney
  4. Peritoneum
  5. B lymphocyte (IgM memory) of spleen
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Disease Atlas

Most Correlated Diseases

  1. Hemorrhagic shock
  2. Bacterial infection due to Bacillus
  3. Sepsis due to coagulase negative Staphylococcus
  4. Injury of integument
  5. Systemic lupus erythematosus
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Pharmaco Atlas

Most Correlated Compounds

  1. Adenovirus E1A Proteins
  2. MLN-0128
  3. CGP 60474
  4. KIN001-270
  5. flavopiridol
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. PCDH11X
  2. ANKRD2
  3. NDRG1
  4. AKT2
  5. SMAD2
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Curated Studies

Most Correlated Studies

  1. L1000 CMAP - Breast adenocarcinoma SKBR3 cells treated with small molecule perturbagens
  2. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
  3. L1000 CMAP - Breast carcinoma BT20 cells treated with small molecule perturbagens
  4. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
  5. RAW264.7 macrophages overexpressing Tbc1d23 and/or stimulated with LPS
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Literature

Most Relevant Literature

  1. The Mre11-Rad50-Nbs1 complex mediates the robust recruitment of Polo to DNA lesions during mitosis.
  2. MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment.
  3. Functions of the MRE11 complex in the development and maintenance of oocytes.
  4. The Mre11-Rad50-Nbs1 complex mediates the robust recruitment of Polo to DNA lesions during mitosis i…
  5. A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Comple…
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Clinical Trials

Most Relevant Clinical Trials

  1. OLAParib COmbinations
  2. SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
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