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beta-catenin destruction complex
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Fetal brain
Kidney medulla
Cerebellum
Lymph nodes
Kidney cortex
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Disease Atlas
Most Correlated Diseases
Ebola virus disease
Herpes simplex type 2 infection
Pyloric ulcer
Immunoglobulin G4 deficiency
Alpha-1-antitrypsin deficiency
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Pharmaco Atlas
Most Correlated Compounds
temsirolimus
sitagliptin
CGP 60474
dinaciclib
OTS-167
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Knockdown Atlas
Most Correlated Gene Perturbations
MAST4
TCIRG1
SMN2
PPP2R2C
CRKL
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Curated Studies
Most Correlated Studies
L1000 CMAP - Embryonic stem HUES3 cells treated with small molecule perturbagens
L1000 CMAP - Bone marrow CD34 cells treated with small molecule perturbagens
L1000 CMAP - Adipocyte ASC cells treated with small molecule perturbagens
L1000 CMAP - Motor neuron MNEU.E cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
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Literature
Most Relevant Literature
Analysing the impact of nucleo-cytoplasmic shuttling of β-catenin and its antagonists APC, Axin and …
Galangin suppresses the proliferation of β-catenin response transcription-positive cancer cells by p…
Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxic…
Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells…
Regulation of protein stability by GSK3 mediated phosphorylation.
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Clinical Trials
Most Relevant Clinical Trials
Efficacy of Subgingival Erythritol Air Polishing in Treatment of Periodontal Pockets
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