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beta-tubulin binding
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Summary
General Info
Body Atlas
Most Correlated Tissues
Substantia nigra pars compacta
Prefrontal cortex
Accumbens
Vestibular nuclei superior
Hypothalamus
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Disease Atlas
Most Correlated Diseases
Pyloric ulcer
Barrett's esophagus
Helicobacter pylori gastrointestinal tract infection
Sepsis due to coagulase negative Staphylococcus
Injury of external ear
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Pharmaco Atlas
Most Correlated Compounds
CGP 60474
VX-745
AT 7867
4-(4-(trifluoromethyl)phenyl)-N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide
ARQ 197
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Knockdown Atlas
Most Correlated Gene Perturbations
PCDH11X
FUBP3
PPP2R2C
NR5A1
BPHL
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Curated Studies
Most Correlated Studies
L1000 CMAP - Neuronal NEU cells treated with small molecule perturbagens
Carotid arteries from atherogenic ApoE knockout mice with carotid artery injury
Glomerulonephrotic and healthy tissue from C57BL6.MRLc1 congenic mice
L1000 CMAP - Neural progenitor NPC.CAS9 cells treated with small molecule perturbagens
Neural development of iPSCs derived from Autistic patients with BCKD-kinase mutations
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Literature
Most Relevant Literature
Dictyostatin flexibility bridges conformations in solution and in the β-tubulin taxane binding site.
GTP regulates the microtubule nucleation activity of γ-tubulin.
Similarity-based virtual screening for microtubule stabilizers reveals novel antimitotic scaffold.
Comparative binding energy (COMBINE) analysis supports a proposal for the binding mode of epothilone…
Vinorelbine in cancer therapy.
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Clinical Trials
Most Relevant Clinical Trials
Study of ABT-751 in Patients With Refractory Hematologic Malignancies
Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass S…
Stibium Metallicum Praeparatum Versus Placebo in the Prevention of Paclitaxel- or Nab-paclitaxel-ind…
A Study of CCI-001 in Patients With Recurrent and/or Metastatic Solid Tumours
Paclitaxel, Nab-paclitaxel, or Ixabepilone With or Without Bevacizumab in Treating Patients With Sta…
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