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Homo Sapiens
Mus Musculus
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Saccharomyces Cerevisiae
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mismatch repair
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Summary
General Info
Body Atlas
Most Correlated Tissues
Tonsil
Duodenum
Vena cava
Hematopoietic stem cell of bone marrow
Adrenal gland cortex
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Disease Atlas
Most Correlated Diseases
Vesicular stomatitis Indiana virus disease
Listeriosis
Zika virus disease
Alpha-1-antitrypsin deficiency
Poisoning by drug AND/OR medicinal substance
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Pharmaco Atlas
Most Correlated Compounds
5-(6)-carboxyfluorescein diacetate succinimidyl ester
AZD8055
WYE 125132
MK 1775
PI103
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Knockdown Atlas
Most Correlated Gene Perturbations
TIRAP
GRHPR
AURKB
NOP2
RPS6
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Curated Studies
Most Correlated Studies
L1000 CMAP - Neural progenitor NPC.CAS9 cells treated with small molecule perturbagens
Cancer Gene Census - mutations in cancer genes
The Immunological Genome Project - Immune cell lineage differentiation and maturation
L1000 CMAP - Neural progenitor NPC cells treated with small molecule perturbagens
L1000 CMAP - Non-small cell lung cancer A549.311 cells with CRISPR targeted gene knockouts
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Literature
Most Relevant Literature
Mismatch repair enzymes regulate telomere recombination in Saccharomycescerevisiae.
Neurofibromatosis type 1 mosaicism in patients with constitutional mismatch repair deficiency.
Biomarkers for chemotherapy and drug resistance in the mismatch repair pathway.
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunothe…
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity.
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Clinical Trials
Most Relevant Clinical Trials
Tislelizumab for the Treatment of Recurrent Mismatch Repair Deficient Endometrial Cancer
Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation
Pembrolizumab With Sitravatinib in Recurrent Endometrial Cancer and Other Solid Tumors With Deficien…
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent En…
Pembrolizumab Before Surgery for the Treatment of Mismatch Repair Deficient Locally Advanced Solid C…
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