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QuickView for response to muramyl dipeptide (biogroup)


Body Atlas

Most Correlated Tissues

  1. Pituitary gland
  2. Cerebellum
  3. Mononuclear cell of peripheral blood
  4. Leukocyte (polymorphonuclear) of peripheral blood
  5. Testes
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Disease Atlas

Most Correlated Diseases

  1. Bacterial infection due to Bacillus
  2. Disease due to Togaviridae
  3. Pyloric ulcer
  4. Tularemia
  5. Alpha-1-antitrypsin deficiency
Explore Disease Atlas Results

Pharmaco Atlas

Most Correlated Compounds

  1. GSK-1059615
  2. flavopiridol
  3. A 443654
  4. CGP 60474
  5. combretastatin A-4
Explore Pharmaco Atlas Results

Knockdown Atlas

Most Correlated Gene Perturbations

  1. MIR9-1
  2. CHMP2A
  3. SETBP1
  4. MTF2
  5. CPPED1
Explore Knockdown Atlas Results

Curated Studies

Most Correlated Studies

  1. Bone marrow- and peritoneal-derived mouse macrophages in resonse to a timecourse of LPS treatment
  2. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
  3. L1000 CMAP - Kidney epithelial HA1E.101 cells with CRISPR targeted gene knockouts
  4. L1000 CMAP - Non-small cell lung cancer A549.311 cells with CRISPR targeted gene knockouts
  5. L1000 CMAP - Breast cancer MCF7.101 cells with CRISPR targeted gene knockouts
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Literature

Most Relevant Literature

  1. The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment.
  2. Detection of muramyl dipeptide-sensing pathway defects in monocytes of patients with Crohn's disease…
  3. Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipep…
  4. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's dise…
  5. NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary is…
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Clinical Trials

Most Relevant Clinical Trials

  1. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Im…
Explore Clinical Trials Results
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