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cGMP-mediated signaling
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Body Atlas
Most Correlated Tissues
Colon cecum
Heart atrium
Aorta
Pericardium
Dorsal root ganglia
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Disease Atlas
Most Correlated Diseases
Infection due to Citrobacter
Pyloric ulcer
Severe acute respiratory syndrome
Stachybotryotoxicosis
Contact dermatitis
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Pharmaco Atlas
Most Correlated Compounds
CGP 60474
GSK690693
A 443654
((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)
flavopiridol
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Knockdown Atlas
Most Correlated Gene Perturbations
CPSF4
PPP2R2C
LRP5
NR5A1
TLK2
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
L1000 CMAP - Breast carcinoma BT20 cells treated with small molecule perturbagens
L1000 CMAP - Neural progenitor NPC.CAS9 cells treated with small molecule perturbagens
L1000 CMAP - Kidney epithelial HA1E.101 cells with CRISPR targeted gene knockouts
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Literature
Most Relevant Literature
Sildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducibl…
EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.
The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP p…
cGMP regulates hydrogen peroxide accumulation in calcium-dependent salt resistance pathway in Arabid…
cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons…
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Clinical Trials
Most Relevant Clinical Trials
Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patient…
The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic …
Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure
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