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(e.g. FOXP1, Coagulation, Breast Cancer, Kidney, Anticancer prodrugs, Doxorubicin, rs7903146)
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QuickView for Notch receptor processing (biogroup)


Body Atlas

Most Correlated Tissues

  1. Microglial cell
  2. Monocyte of peripheral blood
  3. Joint synovium
  4. Spinal cord
  5. Corpus callosum
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Disease Atlas

Most Correlated Diseases

  1. Antiphospholipid syndrome
  2. Sepsis due to Escherichia coli
  3. Infection due to Staphylococcus aureus
  4. Pyloric ulcer
  5. Alpha-1-antitrypsin deficiency
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Pharmaco Atlas

Most Correlated Compounds

  1. brivanib alaninate
  2. Chemokine CCL17
  3. Exotoxins
  4. Adenylate Cyclase Toxin
  5. Bay 65-1942
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. Su(var)3-9
  2. ROR1
  3. NOP2
  4. RPS6
  5. TLK2
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Curated Studies

Most Correlated Studies

  1. Gene expression in the pseudopod versus cell body of human metastatic cancer cells
  2. Oncogenic PI3K mutations in cancer cells following growth factor deprivation
  3. Subcellular fraction from human cell lines - membrane associated and cytoplasmic RNA
  4. Kidneys from male C57BL6 mice 28 days after left proximal ureter ligations
  5. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
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Literature

Most Relevant Literature

  1. Assembly of a Notch transcriptional activation complex requires multimerization.
  2. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protei…
  3. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis.
  4. Role of Cre-loxP-mediated conditional gene targeting in understanding the function of Notch receptor…
  5. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane…
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Clinical Trials

Most Relevant Clinical Trials

  1. A Study of AL101 Monotherapy in Patients With Notch Activated Triple Negative Breast Cancer
  2. A Study Of AL101 In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations
  3. A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterat…
  4. A Phase 1/2 Study CB-103 With or Without Venetoclax in Patients With NOTCH ACC
  5. Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle …
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