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methotrexate binding
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Tongue superior part with papillae
Prostate gland
Omental adipose tissue
Adipose tissue subcutaneous
Bone marrow
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Disease Atlas
Most Correlated Diseases
Ebola virus disease
Zika virus disease
Rhinitis
Retinal detachment
Disease due to Arenavirus
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Pharmaco Atlas
Most Correlated Compounds
Niclosamide
Trimetrexate
pemetrexed
Cyclandelate
edoxudin
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Knockdown Atlas
Most Correlated Gene Perturbations
BAIAP2-AS1
DDX17
ABCE1
MUTYH
NR5A1
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Curated Studies
Most Correlated Studies
Reprogramming of fibroblasts into embryonic Sertoli-like cells
L1000 CMAP - Hepatocellular carcinoma Hep G2 cells with shRNA-mediated gene knockdown (2 of 2)
Neuroblastoma SH-SY5Y cells with DDX5-DDX17 and REST siRNA knockdown
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
Macrophages of C57BL/6 mice with TREM2 knockout or R47H knock-in after treatment with CSF1
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Literature
Most Relevant Literature
Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device.
Methotrexate binding causes structural and functional changes in lung cystatin.
Development of a fluorescently labeled thermostable DHFR for studying conformational changes associa…
Species-specific differences in translational regulation of dihydrofolate reductase.
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.
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Clinical Trials
Most Relevant Clinical Trials
A Study of the Safety and Efficacy of Golimumab in Subjects With Rheumatoid Arthritis That Are Metho…
Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study
Safety and Efficacy of Tofacitinib vs Methotrexate in the Treatment of Psoriatic Arthritis
Trial of Low-Dose Methotrexate and I 131 Tositumomab for Previously Untreated, Advanced-Stage, Folli…
Clinical Trial to Evaluate Efficacy and Safety of Acellbia® (JSC "BIOCAD") With Methotrexate in Firs…
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