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QuickView for BRCA1-A complex (biogroup)


Body Atlas

Most Correlated Tissues

  1. Thymus gland
  2. Subthalamic nucleus
  3. Stomach cardiac
  4. Nodose nucleus
  5. Testes
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Disease Atlas

Most Correlated Diseases

  1. Pyloric ulcer
  2. Vesicular stomatitis Indiana virus disease
  3. Alpha-1-antitrypsin deficiency
  4. Injury of integument
  5. Disorder of uterus
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Pharmaco Atlas

Most Correlated Compounds

  1. ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)
  2. bromohydrin pyrophosphate
  3. AZD1480
  4. Glesatinib
  5. MK 1775
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. hsa-miR-31-5p
  2. AURKB
  3. RNR1
  4. GM2A
  5. DIDO1
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Curated Studies

Most Correlated Studies

  1. NSCLC PC9 cells selected for gefitinib sensitivity or resistance treated with EGF and gefitinib
  2. L1000 CMAP - Breast adenocarcinoma SKBR3 cells treated with small molecule perturbagens
  3. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
  4. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
  5. L1000 CMAP - Breast carcinoma BT20 cells treated with small molecule perturbagens
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Literature

Most Relevant Literature

  1. Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
  2. Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivit…
  3. Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 com…
  4. Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.
  5. Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation.
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Clinical Trials

Most Relevant Clinical Trials

  1. Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing
  2. Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast C…
  3. A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Ris…
  4. Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or…
  5. Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in …
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