Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.

D S Kim, C B Lee, Y S Park, Y H Ahn, T W Kim, C S Kee, J S Kang, A S Om

Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. dskim@hmc.hanyang.ac.kr

Journal of Korean medical science 2001 Jun

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The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.

Citation

D S Kim, C B Lee, Y S Park, Y H Ahn, T W Kim, C S Kee, J S Kang, A S Om. Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues. Journal of Korean medical science. 2001 Jun;16(3):313-6