beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers].

Makoto Kobayashi, Nobuhito Kishimoto, Hisako Ohnishi, Shinya Tada, Nobuo Ueda, Tadashi Kamei, Jiro Fujita, Hirokuni Taguchi

3rd Department of Internal Medicine, Kochi Medical School, Okou-cho, Nankoku, Kochi 783-8505, Japan.

Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society 2002 Aug

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This study was designed to evaluate, in healthy volunteers, differences of bronchodilator responsiveness to a beta 2-agonist between those with the Arg 16/Gly 16 allele and those with the Gly 16/Gly 16 allele at codon 16 of beta 2 adrenoceptor polymorphism. Peak flow and pulmonary functions were measured by body plethysmography after the inhalation of procaterol. In the Arg 16/Gly 16 group, the resulting acute increase of V 25 and acute decrease of airway resistance were greater, and the bronchodilator effect of a single inhaled beta 2-agonist was longer, than those observed in the Gly 16/Gly 16 group. The present study showed that a single inhalation of procaterol has a varying bronchodilator effect on healthy adults, depending on the genotype of beta 2 adrenoceptor polymorphism at codon 16.

Citation

Makoto Kobayashi, Nobuhito Kishimoto, Hisako Ohnishi, Shinya Tada, Nobuo Ueda, Tadashi Kamei, Jiro Fujita, Hirokuni Taguchi. beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2002 Aug;40(8):637-43