Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress.

Grazia Lombardi, Federica Varsaldi, Gianluca Miglio, Maria Grazia Papini, Angelo Battaglia, Pier Luigi Canonico

DISCAFF Department, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy. lombardi@pharm.unipmn.it

European journal of pharmacology 2002 Dec 20

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To study if cabergoline, a long-lasting specific dopamine D2 receptor agonist, has neuroprotective effects against oxidative stress, we exposed (3 h) SH-SY5Y human neuroblastoma cell s to tert-butylhydroperoxide (t-BOOH; 500 microM). t-BOOH caused a 42+/-4% neuronal death, which was prevented by cabergoline (2 h before) in a concentration-dependent manner (EC(50): 1.24 microM). This effect was not antagonised by haloperidol (concentration up to 10 microM), and was associated with an increased availability of intracellular GSH contents (+30+/-11%) and a decrease in the membrane lipid peroxidation (-23+/-9%). Our data suggest that cabergoline has neuroprotective effects useful for Parkinson's disease therapy.

Citation

Grazia Lombardi, Federica Varsaldi, Gianluca Miglio, Maria Grazia Papini, Angelo Battaglia, Pier Luigi Canonico. Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress. European journal of pharmacology. 2002 Dec 20;457(2-3):95-8