Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia.

Michael H Davidson

Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA. mdavidson@protocare.com

Expert opinion on investigational drugs 2002 Mar

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Rosuvastatin is a synthetic enantiomer that is hepatoselective, relatively hydrophilic and has minimal metabolism via the cytochrome P450 3A4 system (similar to pravastatin). Rosuvastatin, like atorvastatin, has a plasma half-life of about 20 h and is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The majority of HMG-CoA reductase inhibitory activity in plasma is associated with the parent rosuvastatin compound. In a Phase II study, rosuvastatin across a dose range of 1 - 80 mg lowered low-density lipoprotein cholesterol (LDL-C) by 34 - 65%. Phase III trials have demonstrated greater reductions in LDL-C for rosuvastatin compared to atorvastatin as well as greater increases in high-density lipoprotein cholesterol (HDL-C). The drug appears to be well tolerated at all doses up to 80 mg/day. A starting dose of 10 mg will reduce LDL-C by approximately 50%, which should adequately treat most patients to within the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) goals.

Citation

Michael H Davidson. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. Expert opinion on investigational drugs. 2002 Mar;11(3):125-41