Epidermal growth factor inhibitors].

C Delbaldo, S Faivre, E Raymond

Département de médecine, institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 cedex, Villejuif, France.

La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne 2003 Jun

filter terms:

Tyrosine kinases are implicated in the normal cellular proliferation and in malignant transformation. Among the tyrosine kinase receptors, one of best described is the Epidermal Growth Factor Receptor (EGFR), which is widely expressed in particular in epithelial cells and in many human carcinomas. Compounds have been developed that target either the extracellular ligand-binding region of EGFR (Cetuximab) or the intracellular tyrosine kinase ATP-binding (Iressa), Tarceva. Phase I studies showed that these molecules have a favorable pharmacokinetic and pharmacodynamic profile, with excellent tolerance and easy administration. Phase II and III studies are currently testing their efficacy. Preliminary results show interesting activity in different tumors, alone or in combination with either chemotherapy or radiotherapy. If these results are confirmed in larger trials including a high number of patients, these agents might be very useful in combination with chemotherapy, radiotherapy or other biological targeting agents such as cellular cycle inhibitors or antiangiogenics.

Citation

C Delbaldo, S Faivre, E Raymond. Epidermal growth factor inhibitors]. La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne. 2003 Jun;24(6):372-83