The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats].

Jian Guan, De-yun Cheng, Xiao-ju Chen, Yong Zhang, Hui Wang, Qiao-li Su

Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2004 Nov

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To investigate the effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats. Thirty male SD rats were randomly divided into three groups: control group, hypoxic group and therapeutic group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions for three weeks. Then, the therapeutic group was given losartan for two weeks. We measured the expression of Collagen I, III and AT1 in arterioles by means of immunohistochemistry. The positive degree of Collagen I in pulmonary arterioles in the hypoxic group was higher than that in the control group [(1.5202+/-0.069) vs (1.1324+/-0.071), P<0.01]; but in the therapeutic group it was lower than that in the hypoxic group [(1.1637+/-0.062) vs (1.5202+/-0.069), P<0.01]. There was no significant difference in collagen III and AT1 among the three groups (P>0.05). Losartan could reduce pulmonary arterial collagen I expression, it may be one of the therapeutic mechanisms on hypoxic pulmonary hypertension of losartan.

Citation

Jian Guan, De-yun Cheng, Xiao-ju Chen, Yong Zhang, Hui Wang, Qiao-li Su. The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2004 Nov;35(6):774-7