Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)].

Zoltán Szabó, Miklós Argyelán, Balázs Kanyó, László Pávics, Zoltán Janka

Szegedi Tudományegyetem, Pszichiátriai Klinika.

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakológiai Egyesület lapja = official journal of the Hungarian Association of Psychopharmacology 2004 Jun

filter terms:

Bupropion has an antidepressant effect through blocking the dopamine transporter. By 99mTc-TRODAT-SPECT, we measured the baseline DAT activity of depressed patients. After 3 weeks' bupropion treatment we studied the change in DAT activity, which corresponds to the occupancy of bupropion. The average occupancy of bupropion on DAT was similar to the international findings at 20.84% in 9 depressed patients.

Citation

Zoltán Szabó, Miklós Argyelán, Balázs Kanyó, László Pávics, Zoltán Janka. Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakológiai Egyesület lapja = official journal of the Hungarian Association of Psychopharmacology. 2004 Jun;6(2):79-81