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parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.
Kendal M Galbraith, Amanda C Ng, Betsy J Eggers, Craig R Kuchel, Christian H Eggers, D Scott Samuels
Antimicrobial agents and chemotherapy 2005 OctSizes of these terms reflect their relevance to your search.
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
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Kendal M Galbraith, Amanda C Ng, Betsy J Eggers, Craig R Kuchel, Christian H Eggers, D Scott Samuels. parC mutations in fluoroquinolone-resistant Borrelia burgdorferi. Antimicrobial agents and chemotherapy. 2005 Oct;49(10):4354-7
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PMID: 16189120
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