Conventional nonselective NSAIDs are classically associated with a risk of gastrointestinal disorders. These drugs have a broad range of relative selectivity towards the COX family, mainly towards two isoforms of these enzymes: COX-1 and -2. As examples, ketorolac, flurbiprofen, ketoprofen and indomethacin have increased COX-1 selectivity when compared with naproxen and ibuprofen.
Andre Uzan. The unexpected side effects of new nonsteroidal anti-inflammatory drugs. Expert opinion on emerging drugs. 2005 Nov;10(4):687-8
PMID: 16262557
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