Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.
Ewa Ellis, Martin Wagner, Frank Lammert, Antal Nemeth, Judith Gumhold, Christian P Strassburg, Christian Kylander, Despina Katsika, Michael Trauner, Curt Einarsson, Hanns-Ulrich Marschall
Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska Institutet, Karolinska University Hospital-Huddinge K63, S-141 86 Stockholm, Sweden.
Journal of hepatology 2006 JanWe report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 micromol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.
Citation
Ewa Ellis, Martin Wagner, Frank Lammert, Antal Nemeth, Judith Gumhold, Christian P Strassburg, Christian Kylander, Despina Katsika, Michael Trauner, Curt Einarsson, Hanns-Ulrich Marschall. Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin. Journal of hepatology. 2006 Jan;44(1):243-5
Mesh Tags
Substances
PMID: 16288819
View Full Text
