Fluorine-18 DOPA PET imaging of paraganglioma syndrome.

Ingo Brink, Oliver Schaefer, Martin Walz, Hartmut P H Neumann

Department of Radiology, Albert-Ludwigs-University, Freiburg, Germany. ingo.brink@uniklinik-freiburg.de

Clinical nuclear medicine 2006 Jan

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A 12-year-old boy was admitted after recently having had a resection performed of an extraadrenal retroperitoneal paraganglioma and left adrenalectomy for pheochromocytoma. Despite these procedures, the blood pressure and urinary noradrenalin were elevated. Screening with fluorine-18 DOPA PET demonstrated increased tracer uptake in the right adrenal gland, in a second abdominal lesion, which was prevertebral, and 2 cervical hot spots near the carotid bifurcation, one on each side of the neck. The patient carries a mutation of the gene Succinate dehydrogenasis subunits D (SDHD) and is thus classified with the paraganglioma syndrome type 1.

Citation

Ingo Brink, Oliver Schaefer, Martin Walz, Hartmut P H Neumann. Fluorine-18 DOPA PET imaging of paraganglioma syndrome. Clinical nuclear medicine. 2006 Jan;31(1):39-41