Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations.

David J Farrell, Jemma Shackcloth, Karen A Barbadora, Michael D Green

GR Micro Limited, 7-9 William Road, London, NW1 3ER, United Kingdom. D.Farrell@grmicro.co.uk

Antimicrobial agents and chemotherapy 2006 Feb

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Seven high-level macrolide-resistant Streptococcus pyogenes isolates had reduced activity to telithromycin but were negative for methylation and efflux genes. All were of the constitutive phenotype, were clonally related (emm type 12 and MLST type 36), and had identical dual mutations (A2058G and U2166C) in domain V of 23S rRNA.

Citation

David J Farrell, Jemma Shackcloth, Karen A Barbadora, Michael D Green. Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations. Antimicrobial agents and chemotherapy. 2006 Feb;50(2):817-8