Inhibition of putrescine aminopropyltransferase influences rat liver regeneration.

Masaki Kobayashi, Koichi Takao, Yasuo Shiota, Yoshiaki Sugita, Masakazu Takahashi, Dai Nakae, Keijiro Samejima

Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan.

Biological & pharmaceutical bulletin 2006 May

filter terms:

A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as a percentage index of remnant liver weight to body weight, correlated well with a decrease of the spd:spm value, with a correlation coefficient of 0.952 for the remnant livers on day 3 after partial hepatectomy. The decrease in recovery rate could be explained by a prolonged cell cycle based on the data of the proliferating cell nuclear antigen labelling index and mitotic cell index in both livers of day 2 and day 3 after partial hepatectomy. The results presented here will give a new aspect in the field of polyamine regulation to control cell growth in vivo.

Citation

Masaki Kobayashi, Koichi Takao, Yasuo Shiota, Yoshiaki Sugita, Masakazu Takahashi, Dai Nakae, Keijiro Samejima. Inhibition of putrescine aminopropyltransferase influences rat liver regeneration. Biological & pharmaceutical bulletin. 2006 May;29(5):863-7