Dineshree V Naiker, Stanley V Catts, Vibeke S Catts, Kuldip S Bedi, Lesley J Bryan-Lluka
School of Medicine, The University of Queensland, Brisbane QLD 4072 Australia.
European journal of pharmacology 2006 Jul 1The purpose of the present study was to determine antipsychotic doses that achieve 80% striatal dopamine D2-receptor occupancy for haloperidol, risperidone and olanzapine in rats. Wistar rats were treated with normal saline vehicle (controls), haloperidol (0.25 and 0.5 mg/kg/day), risperidone (3, 5 and 6 mg/kg/day) and olanzapine (5 and 10 mg/kg/day) for 7 days via osmotic minipumps. Striatal and cerebellar tissue were collected and in vivo dopamine D2-receptor occupancies were determined using 3H-raclopride. The doses required to achieve dopamine D2-receptor occupancy of 80% in 11- and 24-week old rats were: haloperidol 0.25 mg/kg/day, risperidone 5 mg/kg/day and olanzapine 10 mg/kg/day.
Dineshree V Naiker, Stanley V Catts, Vibeke S Catts, Kuldip S Bedi, Lesley J Bryan-Lluka. Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat. European journal of pharmacology. 2006 Jul 1;540(1-3):87-90
PMID: 16730699
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