Logic gates and elementary computing by enzymes.

Ronan Baron, Oleg Lioubashevski, Eugenii Katz, Tamara Niazov, Itamar Willner

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

The journal of physical chemistry. A 2006 Jul 13

filter terms:

Different selected enzymes, glucose oxidase (GOx), catalase (Cat), glucose dehydrogenase (GDH), horseradish peroxidase (HRP), and formaldehyde dehydrogenase (FDH), are used alone or coupled to construct eight different logic gates. The added substrates for the respective enzymes, glucose and H(2)O(2), act as the gate inputs, while the biocatalytically generated gluconic acid or NADH are the output signals that follow the operation of the gates. Different enzyme-based gates are XOR, INHIBIT A, INHIBIT B, AND, OR, NOR, Identity and Inverter gates. By combining the AND and XOR or the XOR and INHIBIT A gates, the half-adder and half-subtractor are constructed, respectively, opening the way to elementary computing by the use of enzymes.

Citation

Ronan Baron, Oleg Lioubashevski, Eugenii Katz, Tamara Niazov, Itamar Willner. Logic gates and elementary computing by enzymes. The journal of physical chemistry. A. 2006 Jul 13;110(27):8548-53