Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1.

The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. DEX increased FLS annexin I protein translocation and mRNA expression. Interleukin (IL)-1beta also induced annexin I translocation and mRNA but also increased intracellular protein. DEX and IL-1 had additive effects on annexin I mRNA, but DEX inhibited the inducing effect of IL-1beta on cell surface annexin I. These results indicate that glucocorticoids and IL-1beta upregulate the synthesis and translocation of annexin I in RA FLS, but interdependent signalling pathways are involved.

Citation

Eric F Morand, Pam Hall, Paul Hutchinson, Yuan H Yang. Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. Mediators of inflammation. 2006;2006(2):73835

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PMID: 16883066

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