Isotretinoin revisited: pluripotent effects on human sebaceous gland cells.

Christos C Zouboulis

Department of Dermatology, Dessau Medical Center, Dessau, Germany. christos.zouboulis@klinikum-dessau.de

The Journal of investigative dermatology 2006 Oct

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Nelson et al. confirmed the previously described antiproliferative effect of isotretinoin on human sebocytes. They attributed a portion of this decrease to cell cycle arrest and detected sebocyte apoptosis, which was not recapitulated by alitretinoin or tretinoin. These events were specific to sebocytes, as isotretinoin failed to induce apoptosis in keratinocytes. Isotretinoin-induced apoptosis was shown to be an RAR-independent mechanism.

Citation

Christos C Zouboulis. Isotretinoin revisited: pluripotent effects on human sebaceous gland cells. The Journal of investigative dermatology. 2006 Oct;126(10):2154-6