Adenosine kinase from rat liver: new biochemical properties.

R Leoncini, D Vannoni, A Santoro, S Giglioni, R Carli, E Marinello

Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry University of Siena, Siena, Italy.

Nucleosides, nucleotides & nucleic acids 2006

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Adenosine kinase is a well-known enzyme which catalyzes the phosphorylation of adenosine to AMP: Its metabolic and kinetic properties are well studied. Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP --> 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Cells could exploited this property in situations in which ATP levels are strongly decreased and ADP decreases slowly.

Citation

R Leoncini, D Vannoni, A Santoro, S Giglioni, R Carli, E Marinello. Adenosine kinase from rat liver: new biochemical properties. Nucleosides, nucleotides & nucleic acids. 2006;25(9-11):1107-12