The emerging role of cannabinoid neuromodulators in symptom management.

Mellar Davis, Vincent Maida, Paul Daeninck, Joseph Pergolizzi

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2007 Jan

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The cannabinoids nabilone (Cesamet) and dronabinol (Marinol) are indicated for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients who have failed to respond adequately to conventional antiemetic therapy. The endocannabinoid (CB) system interacts with numerous other systems and pharmaceutical cannabinoids target ubiquitous CB1 and CB2 receptors in the central nervous system and periphery, relieving nausea and vomiting and pain. The benefits of this novel class of medications in cancer may extend beyond CINV, as indicated by data from preclinical studies and animal models.

Citation

Mellar Davis, Vincent Maida, Paul Daeninck, Joseph Pergolizzi. The emerging role of cannabinoid neuromodulators in symptom management. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2007 Jan;15(1):63-71