Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.

Department of Psychiatry and Human, Behavior University of Mississippi Medical Center, Jackson, MS 39216, United States. Zwang@psychiatry.umsmed.edu

European journal of pharmacology 2007 Feb 28

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Histamine H1 receptor antagonists have some behavioral effects that predict abuse liability. In the present study, diphenhydramine and cocaine each maintained i.v. self-administration under a progressive-ratio schedule in rhesus monkeys. When cocaine and DPH were combined in a 1:1 ratio of the ED50s, the combination was super-additive in all monkeys. The data predict that the combination of cocaine and histamine H1 receptor antagonists would have enhanced potential for abuse relative to either drug alone.

Citation

Zhixia Wang, William L Woolverton. Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects. European journal of pharmacology. 2007 Feb 28;557(2-3):159-60