The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo.

Niels P Riksen, Barbara Franke, Petra van den Broek, Paul Smits, Gerard A Rongen

Department of Pharmacology, Radboud University Nijmegen Medical Center, The Netherlands. N.Riksen@aig.umcn.nl

Pharmacogenetics and genomics 2007 Jul

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The 1976C>T polymorphism in the adenosine A2A receptor gene (ADORA2A) modulates the psychological response to administration of the adenosine receptor antagonist caffeine. We quantified the vascular response to adenosine and caffeine to determine the relevance of this variant allele in the physiological response to these agents. We selected 10 study participants with the TT genotype and 10 CC controls, matched for activities of other proteins involved in the metabolism of adenosine. The vasodilator response to the intrabrachial administration of adenosine (0.5, 1.5, 5.0, 15.0, and 50.0 microg/min/dl; venous occlusion plethysmography) was not different between the groups (P=0.4). In addition, the effect of subsequent administration of caffeine (90 microg/min/dl) was not different (P=0.7). We conclude that the 1976C>T polymorphism does not affect the vascular response to adenosine and caffeine in humans in vivo. Therefore, this polymorphism does not contribute to the variation in the effects of adenosine receptor stimulation.

Citation

Niels P Riksen, Barbara Franke, Petra van den Broek, Paul Smits, Gerard A Rongen. The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenetics and genomics. 2007 Jul;17(7):551-4