Amelioration of arsenic toxicity by L-Ascorbic acid in laboratory rat.

Sohini Singh, S V S Rana

Department of Zoology, Toxicology Laboratory, Ch. Charan Singh University, Meerut-250 004, India.

Journal of environmental biology / Academy of Environmental Biology, India 2007 Apr

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A study so as to confirm the protective effects of L-ascorbic acid against inorganic arsenic (As23) toxicity was made in male Wistar rats. Multiphase observations made on iAs concentration in target organs viz. liver and kidney, liver function, histopathological changes, ultrastructural alterations, lipid peroxidation, oxidative stress and iAs-DNA interaction strongly favoured its ameliorative effects. These effects could mainly be attributed to its antioxidative property. It offers help in regeneration of GSH and alpha-tocopherol. The chelaticn of iAs by ascorbic acid has also been hypothesized. Inhibition of DNA damage by ascorbic acid in liver and kidney appears to be the most significant part of this study On the basis of these results, we conclude that administration of L-ascorbic acid to arsenic affected population may prevent the occurrence of fatal human diseases.

Citation

Sohini Singh, S V S Rana. Amelioration of arsenic toxicity by L-Ascorbic acid in laboratory rat. Journal of environmental biology / Academy of Environmental Biology, India. 2007 Apr;28(2 Suppl):377-84