Alitretinoin: a comprehensive review.

Caleb Cheng, Jason Michaels, Noah Scheinfeld

Jefferson Medical College, USA.

Expert opinion on investigational drugs 2008 Mar

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Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). Studies are being carried out to determine how best to utilize this characteristic in treatments for conditions such as chronic hand dermatitis. To review the literature on alitretinoin. The scope of the review encompasses ways that alitretinoin is currently and may potentially be utilized. Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. Topical treatment with alitretinoin can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US.