Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.

Daisuke Yamamoto, Shinji Takai, Mizuo Miyazaki

Biomedical Computation Center, Osaka Medical College, 2-7 Daigakuchou, Takatsuki, Osaka 569-8686, Japan. center@art.osaka-med.ac.jp <center@art.osaka-med.ac.jp>

European journal of pharmacology 2008 Jul 7

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To investigate the inhibitory profiles of angiotensin-converting enzyme (ACE) inhibitors on matrix metalloproteinase-9 (MMP-9) activity, the inhibitory activity and molecular interaction of captopril on human MMP-9 were studied. Plasma MMP-9 and ACE activities in samples from patient with acute myocardial infarction were similarly inhibited by captopril. Molecular models showed that captopril directly bound to the MMP-9 active center. Compared with the other ACE inhibitors, the compact structure of captopril seemed to make the inhibitory profiles on the MMP-9 active site.

Citation

Daisuke Yamamoto, Shinji Takai, Mizuo Miyazaki. Inhibitory profiles of captopril on matrix metalloproteinase-9 activity. European journal of pharmacology. 2008 Jul 7;588(2-3):277-9