Therapeutic role of zonisamide in neuropsychiatric disorders.

Muhammad U Farooq, Philip W Moore, Archit Bhatt, Rany Aburashed, Mounzer Y Kassab

Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48823, USA. muhammad.farooq@ht.msu.edu

Mini reviews in medicinal chemistry 2008 Sep

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Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinson's disease, essential tremor, stroke, obesity, anxiety, bipolar and binge-eating disorders.

Citation

Muhammad U Farooq, Philip W Moore, Archit Bhatt, Rany Aburashed, Mounzer Y Kassab. Therapeutic role of zonisamide in neuropsychiatric disorders. Mini reviews in medicinal chemistry. 2008 Sep;8(10):968-75