Clinical pharmacology and pharmacogenetics of gemcitabine.

Andrea Wong, Ross A Soo, Wei-Peng Yong, Federico Innocenti

Department of Hematology-Oncology, National University Hospital, Singapore.

Drug metabolism reviews 2009

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Gemcitabine is a cytotoxic nucleoside analog, which is widely used in the treatment of malignancies. Interindividual differences in gemcitabine pharmacokinetics and pharmacodynamics have been demonstrated. Pharmacogenetic factors may account for a significant proportion of these differences. This review provides an update on the pharmacogenetics of gemcitabine and its influence on gemcitabine efficacy and toxicity.

Citation

Andrea Wong, Ross A Soo, Wei-Peng Yong, Federico Innocenti. Clinical pharmacology and pharmacogenetics of gemcitabine. Drug metabolism reviews. 2009;41(2):77-88