A Dasgupta, S Chaki, S Mukherjee, J Lourduraja, K Mazumdar, N K Dutta, S G Dastidar
Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, 7&8 Metro Garden City, DH Road, Pailan, Kolkata 700104, India.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2010 FebThe cardiovascular drug lacidipine (Lc) is known to possess antibacterial activity. Further potentiation of action is possible by synergism between Lc and an antibiotic or a non-antibiotic. The minimum inhibitory concentration (MIC) of antibiotics, Lc and other non-antibiotics were detected by the agar dilution technique in different bacteria. Synergism was determined by disc diffusion assay, the fractional inhibitory concentration (FIC) index through checkerboard assessment and, also, the protective capacity of the combination by administering the drugs along with 50 x LD(50) challenge dose of virulent Salmonella typhimurium in animal experiments. Synergism between Lc and penicillin was found to be statistically significant (P
A Dasgupta, S Chaki, S Mukherjee, J Lourduraja, K Mazumdar, N K Dutta, S G Dastidar. Experimental analyses of synergistic combinations of antibiotics with a recently recognised antibacterial agent, lacidipine. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2010 Feb;29(2):239-43
PMID: 20012879
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