Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease.

Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan. nnagaya@hotmail.co.jp

International angiology : a journal of the International Union of Angiology 2010 Apr

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Prostacyclin (PGI2) inhibits platelet aggregation and vasoconstriction. PGI2 synthase (PTGIS), a catalyst of PGI2 synthesis from prostaglandin H2, is widely distributed and predominantly found in vascular endothelial and smooth muscle cells. The PTGIS gene is localized to 20q13.11-13 and a candidate gene for cardiovascular disease. We discovered mutations and polymorphisms in this gene and reported that they were associated with essential hypertension, myocardial infarction, and cerebral infarction. These results suggest that PGI2 function depends on the different alleles of the PTGIS gene and that they may influence the risk of cardiovascular disease. Thus, individualized management strategies, such as the administration of PGI2 analogues, could be selected for variants of this gene, to help prevent the development of cardiovascular disease.

Citation

T Nakayama. Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease. International angiology : a journal of the International Union of Angiology. 2010 Apr;29(2 Suppl):33-42