Enhancement of pharmacologically induced bronchoconstriction by Ro 5-4864.

Pretreatment with Ro 5-4864 enhanced the bronchoconstrictor responses to histamine or carbachol in the anaesthetized artificially ventilated guinea pig. This suggests the involvement of a peripheral-type benzodiazepine receptor as also indicated by the lack of effect of clonazepam. PK 11195 did not antagonize the Ro 5-4864-induced enhancement, but itself enhanced the bronchoconstrictor responses to histamine or carbachol. The data indicate that Ro 5-4864 and PK 11195 behave as metactoid sensitizers of histamine or carbachol.

Citation

G Marano, M Massotti, A Spagnolo, A Carpi. Enhancement of pharmacologically induced bronchoconstriction by Ro 5-4864. European journal of pharmacology. 1990 Apr 10;179(1-2):237-40

Mesh Tags

Substances

PMID: 2364987

search → result