I Fitos, J Visy, A Magyar, J Kajtár, M Simonyi
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
Biochemical pharmacology 1989 Jul 15Stereoselective binding of rac-acenocoumarol to human serum albumin (HSA) and alpha 1-acid glycoprotein (alpha 1-AGP) was investigated by affinity chromatography and by combined ultrafiltration (UF) and circular dichroism (CD) methods. For HSA, the ratio of the enantiomeric constants was KR/KS = 2, while for alpha 1-AGP, KS/KR = 3.
I Fitos, J Visy, A Magyar, J Kajtár, M Simonyi. Inverse stereoselectivity in the binding of acenocoumarol to human serum albumin and to alpha 1-acid glycoprotein. Biochemical pharmacology. 1989 Jul 15;38(14):2259-62
PMID: 2751692
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