Relaxant and beta 2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta.

S A Doggrell

Department of Pharmacology, School of Medicine, University of Auckland, Private Bag, New Zealand.

The Journal of pharmacy and pharmacology 1988 Nov

filter terms:

The KCl-contracted rat aorta is relaxed by labetalol, dilevalol, amosulalol and KF-4317. These relaxations are not reversed by ICI 118,551 at 10(-6) M and, therefore, are not due to beta-adrenoceptor agonism. At 10(-7) M, labetalol, dilevalol, amosulalol and KF-4317 were beta 2-adrenoceptor antagonists as they inhibited the relaxant responses of rat aorta to procaterol.

Citation

S A Doggrell. Relaxant and beta 2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta. The Journal of pharmacy and pharmacology. 1988 Nov;40(11):812-5