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In addition to the well-known 3 alpha,20 beta-hydroxysteroid dehydrogenase ('cortisone reductase'), Streptomyces hydrogenans produces a relatively stable, NAD-dependent 20 alpha-hydroxysteroid dehydrogenase of molecular mass approximately 48 kDa. This enzyme catalyzes the transfer of hydrogen from the 4-pro-S position of NADH.

Citation

R L Rimsay, G W Murphy, C J Martin, J C Orr. The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans. European journal of biochemistry / FEBS. 1988 Jun 1;174(2):437-42

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PMID: 3164265

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