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As exemplified with bambuterol, a bronchodilator prodrug with sustained action, increased therapeutic selectivity can be obtained as a result of altered tissue distribution and pharmacokinetics rather than of increased beta 2-adrenoceptor selectivity.

Citation

L A Svensson. Bambuterol, a bronchodilator prodrug with sustained action, enhances delivery of active drug to the lung. Agents and actions. Supplements. 1988;23:271-6

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PMID: 3262993

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