Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.

C B Eap, C Cuendet, P Baumann

Clinique Psychiatrique Universitaire de Lausanne, Hôpital de Cery, Prilly, Switzerland.

Naunyn-Schmiedeberg's archives of pharmacology 1988 Feb

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The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.

Citation

C B Eap, C Cuendet, P Baumann. Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein. Naunyn-Schmiedeberg's archives of pharmacology. 1988 Feb;337(2):220-4