Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.

G Berg, R G Andersson, G Ryden

Department of Gynecology/Obstetrics, University Hospital, Linköping, Sweden.

Archives internationales de pharmacodynamie et de thérapie 1987 Dec

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The phosphodiesterase (PDE)-inhibiting and smooth muscle relaxing effects of theophylline, enprofylline, papaverine and moxaverine have been studied in vitro on spontaneous contracting human, pregnant myometrium. All drugs showed a close correlation between the PDE-inhibiting and smooth muscle relaxing effect. The order of smooth muscle relaxing potency was papaverine greater than moxaverine greater than enprofylline greater than theophylline. The most potent PDE-inhibitors were moxaverine and papaverine with a 50% PDE-inhibiting concentration (IC50) of 3.3 and 3.8 microM as compared to the least potent PDE-inhibitor, theophylline, with an IC50 of 665 microM. It is concluded that PDE-inhibiting drugs show a close correlation between PDE-inhibiting and relaxing effect on spontaneously contracting pregnant myometrium and that the newly developed drug enprofylline might be of interest in the treatment of premature uterine contractions.

Citation

G Berg, R G Andersson, G Ryden. Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study. Archives internationales de pharmacodynamie et de thérapie. 1987 Dec;290(2):288-92